
This week is Nobel Week. Every year, the Nobel prizes are awarded on December 10th. All of the Nobel prizes, with the exception of the Nobel Peace Prize are given out in Stockholm. The Nobel prize in Physiology or Medicine is awarded by a committee at the Karolinska Institute (members of which include profs in my department). So, needless to say, this is a pretty big deal here.
Andrew Fire and Craig Mello received (or will receive on Sunday) the Nobel Prize in Physiology or Medicine for their discovery of siRNA. I have to admit that I'm not all that knowledgable on the topic. The groundbreaking paper only came out 8 years ago (in 1998). Small interference RNA (siRNA) is double stranded RNA that can be introduced to interfere with the transcription/translation so that DNA never becomes protein. (I'm sure Lisa will correct me on this!) In the furture, siRNA may be used to silence certain DNA sequences to prevent diseases, tumors, etc. This is a long way off, but is possible.
Okay, back to today......Most of the Nobel lectures were today. The Physiology/Medicine lectures were held two buildings away. So, with most of my lab, I lined up over an hour ahead of time to get into the lecture. Believe it or not, we were not early enough! We were about 15 people behind the last people admiitted into the lecture hall! Members of the Mello family were behind us and said something when they closed it off. People around us commented that clearly, they were family since they were American (as judged by their accents). Kathy (the other American postdoc in my lab) and I joked that we should claim to be family too. But, we didn't. Most of my lab left at that point but a few of us went to watch in another lecture hall, where the audio/video was piped in.
I have to admit that I expected a bit more - and I was looking forward to this post, all about the awesome Nobel lectures. Unfortunately, I wasn't nearly as impressed as I expected to be. [Let me precede my commentary by saying that I don't think that my opinions of the lectures should mitigate the importance of the work they performed.] The lectures started off with the president of the KI. The grad student sitting next to me was reciting the beginning of the president's intro line by line before she said it. Apparently, she's given the same EXACT intro for at least the past 3 years! The Nobel lectures themselves received mixed reviews. Andy Fire gave the first lecture, which I thought was pretty good. I thought he did a good job of giving the background to his field and the previous work leading up to the discovery - and, of course, his work. (I also thought his acknowledgements were cute. After giving all of the normal ones, he put up a slide of ~6-8 pt font, that you couldn't really read, of all of the people he felt, in some way, contributed to his successes.) Craig Mello's lecture was next and I felt his was more of a lesson of how not to give a Nobel lecture. Maybe my opinion is a bit harsh but most people in my lecture hall left in the middle of his lecture (and you can judge for yourself at www.nobelprize.org).
From my experience today, I've come up with the do NOTs -and some dos so it's not all negative- of giving a Nobel lecture (if applicable, thank me at the end of your Nobel lecture - or better yet, invite me to the ceremony and gala banquet!):
1. Don't try too hard to be funny - your effort will show more than the humor you intend.
2. Don't reference American pop culture. And, even worse, if you do, don't spend 5 minutes explaining it! Those who don't know, won't get it. Those (especially, those non-Americans) who understand the reference, will resent the explanation.
3. If you are given 45 minutes, don't talk for 75 minutes (no joke, this really happened today!). Even the scientists expecting a 45 min lecture aren't paying attention after 40 min, forget the non-scientists.
4. Make your slides simple and, more importantly, read-able.
5. Make your talk coherent, make it logical, and tell a story.
6. Know which slide is next. Don't make it look like you made the talk on the plane.
7. Focus your talk on your groundbreaking, Nobel-winning experiments.
8. If you must use a cutesy analogy, make sure it works and keep referencing it through your entire talk. Don't mention it at the beginning, with no explanation, and then refer back to it an hour later.
9. Don't reference the chemistry and physics Nobel lectures (presented earlier in the day) 2 million times because most of the audience missed them.
10. Thank your family. I saw at least 20-30 of them, spanning 3 generations, go into the lecture hall. Stockholm is very far from the US. If they took the time to travel that far, they deserve an acknowledgement.
Again, if you think my assessment is harsh or unfair, you can judge for yourself. You can get the lectures on the site I mentioned above and others. Also, people's expectations (mine included) were high, given that both lecturers are Americans (English is their native language) and they are both young - and, hello, it's the Nobel Prize.